Background: Cosmeceuticals are cosmetic-pharmaceutical hybrids intended to enhance health and beauty of the\r\nskin. Nanocosmeceuticals use nano-sized system for the delivery of active ingredients to the targeted cells for\r\nbetter penetration. In this work, nanoemulsion from palm oil esters was developed as a delivery system to produce\r\nnanocosmeceuticals. The stability of the resulting formulation was tested using various methods. In addition, the\r\neffect of components i.e. Vitamin E and Pluronic F-68 on the formulation was also studied.\r\nResults: Both vitamin E and Pluronic F-68 were found to co-emulsify and co-stabilized the formulations. The best\r\nformulation was found to be the one having the composition of 10% Palm Oil Esters (POEs), 10% vitamin E, 24%\r\nTween 80, 2.4% Pluronic F-68 and 53.6% deionised water. Those compositions are considered to be the best as a\r\nnanocosmeceutical product due to the small particle size (94.21 nm), low occurrence of Ostwald ripening and\r\nstable at different storing temperatures (5, 25 and 45�°C) for four weeks.\r\nConclusions: Palm oil esters-in-water nanoemulsions loaded with vitamin E was successfully formulated and has\r\nthe potential for the use as nanocosmeceuticals
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